CAS 71368-80-4 Bromazolam

Description

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Chemical Properties of Bromazolam CAS 71368-80-4

Bromazolam, with the chemical formula C17H13BrClN2O, is a member of the benzodiazepine class, known for its diverse psychoactive properties.

Medical Uses:
Benzodiazepines, including Bromazolam, are primarily prescribed for their anxiolytic (anxiety-reducing), sedative, and hypnotic properties. They are often used to treat conditions such as anxiety disorders, panic attacks, and insomnia. However, due to the potential for tolerance and dependence, medical professionals typically prescribe them for short-term use.

Molecular Weight and Structure:

Bromazolam has a molecular weight of approximately 354.65 g/mol.
The compound’s structure includes a benzodiazepine ring, consisting of a seven-membered diazepine fused with a phenyl ring and bromine, chlorine, and nitro functional groups.

Solubility:

Bromazolam is typically soluble in organic solvents, such as dimethyl sulfoxide (DMSO) and ethanol, but its solubility in water is generally low.
Melting Point:

The compound is observed to be in a solid-state at room temperature, and its melting point falls within a specific range depending on its form.

Stability:

Bromazolam, like other benzodiazepines, is generally stable under normal storage conditions. However, exposure to heat, light, or moisture can contribute to degradation.

Reactivity:

Bromazolam is reactive in biological systems, particularly within the central nervous system. It exerts its pharmacological effects by enhancing the activity of gamma-aminobutyric acid (GABA) receptors, leading to anxiolytic, sedative, and hypnotic effects.
Acidity/Basicity:

As a benzodiazepine, Bromazolam contains a nitrogen atom within its diazepine ring, which can act as a weak base. The basicity contributes to its interaction with acidic protons in biological systems.

Synthesis:

Bromazolam can be synthesized through chemical processes involving precursors and reagents, typically in a laboratory setting. The synthesis may include steps such as condensation, bromination, and ring formation.
Metabolism:

In the body, Bromazolam undergoes metabolism, primarily in the liver. The metabolites formed are often conjugated to glucuronic acid and subsequently excreted in urine.

Half-life:

The compound exhibits a specific half-life, representing the time it takes for the concentration of Bromazolam in the bloodstream to decrease by half. The half-life can influence dosing intervals and the overall duration of its pharmacological effects.